Ozone shuts down early immune response in lungs and body

DURHAM, N.C. – As policy makers debate what levels of ozone in the air are safe for humans to breathe, studies in mice are revealing that the inhaled pollutant impairs the body’s first line of defense, making it more susceptible to subsequent foreign invaders, such as bacteria.

While it has long been known that exposure to ozone, a major component of urban air pollution, is associated with increased cardiovascular and pulmonary hospitalizations and deaths, the actual mechanisms involved remain unclear. New studies by Duke University Medical Center pulmonary researchers on the effects of ozone on the innate immune system, the body’s “tripwire” for foreign invaders, may provide part of the answer.